MovDisordV3, Main, Exploration, bibRecord, 001D29

Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients

Identifieur interne : 001D29 ( Main/Exploration ); précédent : 001D28; suivant : 001D30

Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients

Auteurs : Valerio Pisani [Italie] ; Vincenzo Moschella [Italie] ; Monica Bari [Italie] ; Filomena Fezza [Italie] ; Salvatore Galati [Italie] ; Giorgio Bernardi [Italie] ; Paolo Stanzione [Italie] ; Antonio Pisani [Italie] ; Mauro Maccarrone [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-05-15.

RBID : ISTEX:AE87E5CECD1F7001A375ADF9B83E7AB0161FA51B

Descripteurs français

Pascal (Inist)
- Cannabinoïde, Homme, Liquide céphalorachidien, Lévodopa, Maladie de Parkinson, Pathologie du système nerveux.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Arachidonic Acids (cerebrospinal fluid), Biological Markers, Cannabinoid, Cerebrospinal fluid, Dopamine Agonists (therapeutic use), Endocannabinoids, Female, Human, Humans, Levodopa, Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Polyunsaturated Alkamides (cerebrospinal fluid), anandamide, cerebrospinal fluid, endocannabinoid, levodopa.
MESH :
- chemical , cerebrospinal fluid : Arachidonic Acids, Polyunsaturated Alkamides.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- cerebrospinal fluid : Parkinson Disease.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- Aged, Biological Markers, Endocannabinoids, Female, Humans, Male, Middle Aged.

Abstract

A correct balance between endocannabinoid and dopamine‐dependent systems is believed to underlie physiological motor control. We measured the levels of the endocannabinoid anandamide in the cerebrospinal fluid of Parkinson's disease (PD) patients. Subjects were divided into three groups: newly diagnosed de novo patients, subjects undergoing drug withdrawal, and patients under pharmacological therapy. These groups were compared to age‐matched control subjects. Anandamide levels in untreated patients were more than doubled as compared to controls. However, chronic dopaminergic replacement restored control anandamide levels. Abnormal anandamide increase might reflect a compensatory mechanism occurring in course of PD, aimed at normalizing dopamine depletion. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/AE87E5CECD1F7001A375ADF9B83E7AB0161FA51B/fulltext/pdf

DOI: 10.1002/mds.23014

Affiliations:

Le document en format XML

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<author><name sortKey="Stanzione, Paolo" sort="Stanzione, Paolo" uniqKey="Stanzione P" first="Paolo" last="Stanzione">Paolo Stanzione</name>
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<series><title level="j">Movement Disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Arachidonic Acids (cerebrospinal fluid)</term>
<term>Biological Markers</term>
<term>Cannabinoid</term>
<term>Cerebrospinal fluid</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Endocannabinoids</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Polyunsaturated Alkamides (cerebrospinal fluid)</term>
<term>anandamide</term>
<term>cerebrospinal fluid</term>
<term>endocannabinoid</term>
<term>levodopa</term>
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<term>Levodopa</term>
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<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">A correct balance between endocannabinoid and dopamine‐dependent systems is believed to underlie physiological motor control. We measured the levels of the endocannabinoid anandamide in the cerebrospinal fluid of Parkinson's disease (PD) patients. Subjects were divided into three groups: newly diagnosed de novo patients, subjects undergoing drug withdrawal, and patients under pharmacological therapy. These groups were compared to age‐matched control subjects. Anandamide levels in untreated patients were more than doubled as compared to controls. However, chronic dopaminergic replacement restored control anandamide levels. Abnormal anandamide increase might reflect a compensatory mechanism occurring in course of PD, aimed at normalizing dopamine depletion. © 2010 Movement Disorder Society</div>
</front>
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<name sortKey="Maccarrone, Mauro" sort="Maccarrone, Mauro" uniqKey="Maccarrone M" first="Mauro" last="Maccarrone">Mauro Maccarrone</name>
<name sortKey="Moschella, Vincenzo" sort="Moschella, Vincenzo" uniqKey="Moschella V" first="Vincenzo" last="Moschella">Vincenzo Moschella</name>
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Movement Disorders (revue)

Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients

Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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